1242434-03-2Relevant academic research and scientific papers
5-Functionalized indazoles as glucocorticoid receptor agonists
Bai, Mei,Carr, Grant,DeOrazio, Russell J.,Friedrich, Thomas D.,Dobritsa, Svetlana,Fitzpatrick, Kevin,Guzzo, Peter R.,Kitchen, Douglas B.,Lynch, Michael A.,Peace, Denise,Sajad, Mohammed,Usyatinsky, Alexander,Wolf, Mark A.
, p. 3017 - 3020 (2010)
An indazole based series of glucocorticoid receptor agonists is reported. The SAR exploration of this scaffold yielded compounds with nanomolar affinity for the glucocorticoid receptor with indications of selectivity for the preferred transrepression mech
