124244-34-4Relevant academic research and scientific papers
Highly regioselective alkylation at the more hindered α-site of unsymmetrical ketones by use of their potassium enolates. A comparative study with lithium enolates
Quesnel, Yannick,Bidois-Sery, Laure,Poirier, Jean-Marie,Duhamel, Lucette
, p. 413 - 415 (2007/10/03)
Alkylation of regioisomeric potassium enolates 4 and 6 obtained from corresponding silyl enol ethers 2 and 3 occurs at the most substituted site affording ketones 8. Alkylation of corresponding lithium enolates 5 and 7 occurs at the expected site affording ketones 8 or 9. As an application the one pot synthesis of spiroketones 13 from silyl enol ethers 12 is described.
Regiochemical control in the Pd(II)-catalyzed Claisen rearrangement via in situ enol ether exchange
Sugiura, Masaharu,Nakai, Takeshi
, p. 7991 - 7994 (2007/10/03)
The titled reactions of unsymmetrical enol methyl ethers with allylic alcohols are shown to exhibit the opposite regioselectivities to those of the conventional thermal counterparts to result in the selective formation of the ketones arising from the less
Radical α-Allylation of Alkyl-Substituted α-(Phenylseleno)cycloalkanones
Toru, Takeshi,Okumura, Tatsuya,Ueno, Yoshio
, p. 1277 - 1280 (2007/10/02)
Irradiation and thermal reaction of 3-, 4-, or 6-alkyl-2-(phenylseleno)cycloalkanones with tributyl-2-propenyltin gave 2-allylated products in high yields.Either trans- or cis-selenocycloalkanones afforded the identical distribution of cis- and trans-ally
