Cas 1242441-58-2,(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-[<sup>11</sup>C] methyl-1H-imidazol-4-yl}phenyl)-N,Ndimethylcyclopropanecarboxamide

1242441-58-2

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Basic information

Product Name: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-[¹¹C] methyl-1H-imidazol-4-yl}phenyl)-N,Ndimethylcyclopropanecarboxamide
Synonyms: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-[¹¹C] methyl-1H-imidazol-4-yl}phenyl)-N,Ndimethylcyclopropanecarboxamide
CAS NO:1242441-58-2
Molecular Formula:
Molecular Weight: 411.932
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-[¹¹C] methyl-1H-imidazol-4-yl}phenyl)-N,Ndimethylcyclopropanecarboxamide(CAS DataBase Reference)
NIST Chemistry Reference: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-[¹¹C] methyl-1H-imidazol-4-yl}phenyl)-N,Ndimethylcyclopropanecarboxamide(1242441-58-2)
EPA Substance Registry System: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-[¹¹C] methyl-1H-imidazol-4-yl}phenyl)-N,Ndimethylcyclopropanecarboxamide(1242441-58-2)

Safety Data

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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1242441-58-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1242441-58-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,2,4,4 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1242441-58:
(9*1)+(8*2)+(7*4)+(6*2)+(5*4)+(4*4)+(3*1)+(2*5)+(1*8)=122
122 % 10 = 2
So 1242441-58-2 is a valid CAS Registry Number.

1242441-58-2Upstream product

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1242441-58-2Relevant academic research and scientific papers

Discovery of MK-3168: A PET tracer for imaging brain fatty acid amide hydrolase

Liu, Ping,Hamill, Terence G.,Chioda, Marc,Chobanian, Harry,Fung, Selena,Guo, Yan,Chang, Linda,Bakshi, Raman,Hong, Qingmei,Dellureficio, James,Lin, Linus S.,Abbadie, Catherine,Alexander, Jessica,Jin, Hong,Mandala, Suzanne,Shiao, Lin-Lin,Li, Wenping,Sanabria, Sandra,Williams, David,Zeng, Zhizhen,Hajdu, Richard,Jochnowitz, Nina,Rosenbach, Mark,Karanam, Bindhu,Madeira, Maria,Salituro, Gino,Powell, Joyce,Xu, Ling,Terebetski, Jenna L.,Leone, Joseph F.,Miller, Patricia,Cook, Jacquelynn,Holahan, Marie,Joshi, Aniket,O'Malley, Stacey,Purcell, Mona,Posavecz, Diane,Chen, Tsing-Bau,Riffel, Kerry,Williams, Mangay,Hargreaves, Richard,Sullivan, Kathleen A.,Nargund, Ravi P.,DeVita, Robert J.

supporting information, p. 509 - 513 (2013/07/26)

We report herein the discovery of a fatty acid amide hydrolase (FAAH) positron emission tomography (PET) tracer. Starting from a pyrazole lead, medicinal chemistry efforts directed toward reducing lipophilicity led to the synthesis of a series of imidazole analogues. Compound 6 was chosen for further profiling due to its appropriate physical chemical properties and excellent FAAH inhibition potency across species. [11C]-6 (MK-3168) exhibited good brain uptake and FAAH-specific signal in rhesus monkeys and is a suitable PET tracer for imaging FAAH in the brain.

IMIDAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH AND AS FAAH IMAGING AGENTS

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Page/Page column 52-53, (2010/09/18)

The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds

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