1242450-18-5Relevant academic research and scientific papers
Assembly/disassembly of drug conjugates using imide ligation
Mhidia, Reda,Beziere, Nicolas,Blanpain, Annick,Pommery, Nicole,Melnyk, Oleg
supporting information; experimental part, p. 3982 - 3985 (2010/11/02)
A strategy is described that allows the easy assembly and controlled disassembly of drug conjugates. Imide ligation, that is, the reaction of a peptide thioacid with an azidoformate, is used for conjugate assembly. The imide bond participates also with an endopeptidase-triggered cyclization-based disassembly mechanism.
