124259-94-5

Upstream product

• 84212-80-6 5,7-dimethoxy-4-thioflavone 
• 64-17-5 ethanol 
• 7803-57-8 hydrazine hydrate 
• 21392-57-4 Dimethyl-chrysin 
• 33495-30-6 2-benzoyloxy-4,6-dimethoxyacetophenone 
• 33507-94-7 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylpropane-1,3-dione 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 

Relevant academic research and scientific papers

3,5-diaryl pyrazole or 3,4-diaryl pyrazole derivative and application thereof

The invention discloses 3,5-diaryl pyrazole or 3,4-diaryl pyrazole derivative and application thereof. The 3,5-diaryl pyrazole or 3,4-diaryl pyrazole derivative is prepared from compound which is shown in a formula (I), a formula (II), a formula (III) or a formula (IV) or pharmaceutical-acceptable salt of the compound. A formula of the 3,5-diaryl pyrazole or 3,4-diaryl pyrazole derivative is shownin a following image, wherein R1, R2, R3, R4 and R5 are respectively and independently chosen from hydrogen atom, hydroxy, nitro, amino, alkoxy or ester group with a C1 to C10 alkyl substituent group; alkyl in the alkoxy is a C1 to C10 alkyl; R is independently chosen from hydrogen atom, 2-ethoxy, acetyl, phenyl, benzoyl, p-methoxyphenyl, 4-trifluoromethoxy, 2-cyanoethyl or C1 to C10 alkyl. The 3,5-diaryl pyrazole derivative or the 3,4-diaryl pyrazole derivative can be applied to preventing and treating fungal infection; especially, application in treating candida albicans infection and reversing fluconazole drug resistance has good development value.