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Relevant academic research and scientific papers

Saccharin sulfonic acid (SASA) as a highly efficient catalyst for the condensation of 2-naphthol with arylaldehydes and amides (thioamides or alkyl carbamates) under green, mild, and solvent-free conditions

Saccharin sulfonic acid (SaSA) is used as a highly efficient and recyclable catalyst for the one-pot multicomponent condensation of 2-naphthol with arylaldehydes and amides (thioamides or alkyl carbamates) under green, mild (70 °C), and solvent-free conditions. In this reaction, 1-amidoalkyl-2- naphthols, 1-thioamidoalkyl-2-naphthols, 1-carbamatoalkyl-2-naphthols, bis(1-amidoalkyl-2-naphthol)s, and bis(1-carbamatoalkyl-2-naphthol)s are produced in high to excellent yields and in relatively short reaction times. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

β-Cyclodextrin-butane sulfonic acid: An efficient and reusable catalyst for the multicomponent synthesis of 1-amidoalkyl-2-naphthols under solvent-free conditions

β-cyclodextrin-butane sulfonic acid is reported to be an efficient catalyst for the one-pot synthesis of 1-amidoalkyl-2-naphthols by the multicomponent condensation of aromatic aldehydes, β-naphthol and amides under solvent-free conditions. The present methodology offers several advantages such as shorter reaction time, mild reaction conditions, a simple operational procedure and use of a recyclable catalyst.

Nano silica phosphoric acid: An efficient catalyst for the one-pot synthesis of amidoalkyl naphthols under solvent-free condition

1-Amidoalkyl-2-naphthols were prepared via one-pot multi-component reaction of 2-naphthol, aldehydes, and amides in the presence of nano silica phosphoric acid under solvent-free condition at 80°C. Short reaction times, high yields, and easy work-up are t

Discovery of an in situ carbocationic system using trityl chloride as a homogeneous organocatalyst for the solvent-free condensation of β-naphthol with aldehydes and amides/thioamides/alkyl carbamates in neutral media

Trityl chloride (TrCl), efficiently catalyzes the one-pot multi-component condensation of β-naphthol with aromatic aldehydes and amides/thioamides/ carbamates such as acetamide, benzamide, nicotinamide, thioacetamide, and methylcarbamate under solvent-free and neutral conditions to afford 1-amido-alkyl-2-naphthols, 1-thioamido-alkyl-2-naphthols, and 1-carbamato-alkyl-2-naphthols in high yields and very short reaction times. Mechanistically, it is interesting that trityl chloride through the in situ generation of trityl carbocation with inherent instability is efficient as a reusable homogeneous organocatalyst in neutral media.

Triethylamine-bonded sulfonic acid ([Et3N-SO3H]Cl): A highly efficient and homogeneous catalyst for the condensation of 2-naphthol with arylaldehydes and amides (alkyl carbamates or thioamides)

Ionic liquid triethylamine-bonded sulfonic acid ([Et3N-SO 3H]Cl, N,N-diethyl-N-sulfoethanammonium chloride) is utilized as a highly efficient, inexpensive and homogeneous catalyst to promote the following one-pot multi-component organic transformations under solvent-free conditions: (i) the condensation of 2-naphthol with arylaldehydes and amides leading to 1-amidoalkyl-2-naphthols, (ii) the reaction of 2- naphthol with aromatic aldehydes and alkyl carbamates to produce 1-carbamatoalkyl-2-naphthols, and (iii) the condensation between 2-naphthol, arylaldehydes and thioamides leading to 1-thioamidoalkyl-2- naphthols. High yields, short reaction times, efficiency, generality, clean process, simple methodology, low cost, easy work-up, ease of preparation of the catalyst, and environmentally benign conditions are some advantages of the protocols.