1242652-76-1Relevant academic research and scientific papers
Palladium-catalyzed carbonylative heck-type reactions of alkyl iodides
Bloome, Kayla S.,Alexanian, Erik J.
, p. 12823 - 12825 (2010)
A palladium-catalyzed carbonylative Heck-type cyclization of alkyl halides is described. Treatment of a range of primary and secondary alkyl iodides with catalytic palladium(0) under CO pressure forms a variety of synthetically versatile enone products. The reactivity described represents a rare example of a palladium-catalyzed Heck-type cyclization involving unactivated alkyl halides with β-hydrogens. Alkene substitution is well tolerated, and mono-and bicyclic carbocycles may be easily accessed.
