1242653-33-3Relevant academic research and scientific papers
Pd-catalyzed reaction of sterically hindered hydrazones with aryl halides: Synthesis of tetra-substituted olefins related to iso-combretastatin A4
Brachet, Etienne,Hamze, Abdallah,Peyrat, Jean-Francois,Brion, Jean-Daniel,Alami, Mouad
supporting information; experimental part, p. 4042 - 4045 (2010/11/16)
PdCl2(MeCN)2 in combination with dppp proved to be a powerful and efficient catalyst for the coupling of sterically hindered N-arylsulfonylhydrazones with aryl halides, thus providing a flexible and convergent access to tetrasubstituted olefins related to iso-combretastatin A4 in good yields. This new protocol has been applied successfully to the formal synthesis of biphenylisopropylidene 4-pyridine CYP17 inhibitor, 12b, of biological interest.
