124266-93-9

Upstream product

• 513-38-2 Isobutyl iodide 
• 118388-74-2 2-<4-cyclohexyl-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxobutyl>propanedioic acid bis(phenylmethyl) ester 
• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 
• 118388-73-1 (S)-2-tert-butyl 1-cyclohexyl-4-diazo-3-oxobutan-2-ylcarbamate 
• 118388-72-0 (S)-<3-bromo-1-(cyclohexylmethyl)-2-oxopropyl>carbamic acid 1,1-dimethylethyl ester 

Downstream Products

• 118404-74-3 ((S)-4-{(S)-1-[(S)-2-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-1-cyclohexylmethyl-6-methyl-2-oxo-heptyl)-carbamic acid tert-butyl ester 
• 118388-38-8 ((S)-4-{(S)-1-[(S)-2-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-6-methyl-heptyl)-carbamic acid tert-butyl ester 
• 118386-95-1 (S)-5-tert-Butoxycarbonylamino-6-cyclohexyl-2-isobutyl-4-oxo-hexanoic acid 

Relevant academic research and scientific papers

Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai