1242732-27-9Relevant academic research and scientific papers
A general protocol to afford enantioenriched linear homoprenylic amines
Bosque, Irene,Foubelo, Francisco,Gonzalez-Gomez, Jose C.
, p. 7507 - 7515 (2013/11/06)
The reaction of a readily obtained chiral branched homoprenylamonium salt with a range of aldehydes, including aliphatic substrates, affords the corresponding linear isomers in good yields and enantioselectivities.
Stereoselective α-aminoallylation of aldehydes with chiral tert -butanesulfinamides and allyl bromides
Gonzalez-Gomez, Jose C.,Medjahdi, Mohamed,Foubelo, Francisco,Yus, Miguel
supporting information; experimental part, p. 6308 - 6311 (2010/11/17)
Figure presented. The combination of an aldehyde, an allylic bromide, and tert-butanesulfinamide in the presence of indium metal and titanium tetraethoxide allows straightforward access to homoallylamine derivatives in high yields and stereoselectivities. Moreover, the synthetic utility of the enantioenriched homoallylamine derived from n-decanal was illustrated in a concise synthesis of (+)-isosolenopsin. In this context, similar homoallylamines has been recently used by other groups in the synthesis of naturally occurring alkaloids.
