124276-95-5

Basic information

• Product Name: 1-(3-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID
• Synonyms: 1-(3-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID;1-(3-BROMOPHENYL)CYCLOPROPANE-1-CARBOXYLIC ACID;AKOS BBV-005261;1-(3-Bromophenyl)-1-carboxycyclopropane, 1-(1-Carboxycycloprop-1-yl)-3-bromobenzene;1-(3-BROMOPHENYL)CYCLOPROPANEC
• CAS NO: 124276-95-5
• Molecular Formula: C₁₀H₉BrO₂
• Molecular Weight: 241.08
• Product Categories: pharmacetical;Carboxylic Acids;Carboxylic Acids;Ring Systems
• Mol File: 124276-95-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 367.55 °C at 760 mmHg
• Flash Point: 176.089 °C
• Appearance: /
• Density: 1.671 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.23±0.20(Predicted)
• CAS DataBase Reference: 1-(3-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID(124276-95-5)
• EPA Substance Registry System: 1-(3-BROMOPHENYL)CYCLOPROPANECARBOXYLIC ACID(124276-95-5)

Safety Data

• Hazardous Substances Data: 124276-95-5(Hazardous Substances Data)

Usage

General Description

1-(3-Bromophenyl)cyclopropanecarboxylic acid is a chemical compound with the molecular formula C10H9BrO2. It is a cyclopropane derivative with a carboxylic acid group and a 3-bromophenyl substituent. 1-(3-Bromophenyl)cyclopropanecarboxylic acid is used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceutical compounds. It is known for its potential biological activities and is being studied for its use in drug discovery and development. The presence of the bromine atom and the cyclopropane ring in its structure contributes to its unique properties and potential applications in various fields.

InChI:InChI=1/C10H9BrO2/c11-8-3-1-2-7(6-8)10(4-5-10)9(12)13/h1-3,6H,4-5H2,(H,12,13)

Upstream product

• 597563-13-8 1-(3-bromophenyl)cyclopropanecarboxamide 
• 124276-83-1 1-(3-bromophenyl)cyclopropane-1-carbonitrile 
• 31938-07-5 (3-bromophenyl)acetonitrile 

Downstream Products

• 597563-14-9 C₁₀H₈BrClO 
• 749928-59-4 methyl 1-(3-bromophenyl)cyclopropane-1-carboxylate 
• 597563-13-8 1-(3-bromophenyl)cyclopropanecarboxamide 
• 1359981-61-5 1-(3-bromophenyl)cyclopropanecarboxylic acid ethyl ester 
• 1252638-94-0 (4R)-1-{[1-(3-bromophenyl)cyclopropyl]carbonyl}-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-L-prolinamide 
• 1268444-74-1 (4R)-1-{[1-(3-bromophenyl)cyclopropyl]carbonyl}-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-L-prolinamide 
• 597563-17-2 tert-butyl N-[1-(3-bromophenyl)cyclopropyl]carbamate 
• 546115-65-5 1-(3-bromophenyl)cyclopropan-1-amine 

Relevant articles and documents

Preparation method of arylcyclopropane compound

The present invention discloses a method for preparing an arylcyclopropane compound, 1.0eq phenylacetonitrile and 1.1eq 1-bromo-2-chloroethane as the starting material, N, N- dimethylacetamide as a solvent, solvent dosage of 10V, plus 2.5eq sodium hydride

PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS

The invention includes procedures for stereoselective β-arylation of carboxylic acids having a β-carbon atom. For example, stereoselective arylation procedures include the following reactions: (I)

Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.