124288-95-5

Upstream product

• 102240-82-4 N⁵-benzyloxycarbonyl-N²-(toluene-4-sulfonyl)-L-ornithine amide 
• 1031-48-7 N²-(toluene-4-sulfonyl)-L-ornithine methyl ester; hydrochloride 
• 3184-13-2 L-ornithine hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 110570-69-9 N⁵-benzyloxycarbonyl-N²-(toluene-4-sulfonyl)-L-ornithine methyl ester 
• 110414-90-9 α-N-tosyl-δ-N-carbobenzoxyornthine 
• 124288-74-0 1,1-dimethylethyl (S)-5-amino-2-<<(4-methylphenyl)sulfonyl>-amino>pentanoate 
• 124288-73-9 1,1-dimethylethyl (S)-2-<<(4-methylphenyl)sulfonyl>-amino>-5-<<(phenylmethoxy)carbonyl>amino>pentanoate 

Downstream Products

• 1042906-12-6 N'-4-dimethyl-N-(2-oxopiperidin-3-yl)benzenesulfonamide 
• 1159-15-5 N^α-p-tosyl-L-arginine 
• 74-79-3 L-arginine 
• 70-26-8 L-ornithine 
• 19595-40-5 N²-(toluene-4-sulfonyl)-L-ornithine 

Relevant academic research and scientific papers

Highly efficient, enantioselective syntheses of (S)-(+)- and (R)-(-)-dapoxetine starting with 3-phenyl-1-propanol

(Chemical Equation Presented) A highly efficient, enantioselective sequence has been developed for the synthesis of (S)- and (R)-dapoxetine. The pathways involve the intermediacy of the 6-membered-ring sulfamate esters 4, which were generated by Du Bois asymmetric C-Hamination reactions of the prochiral sulfamate 3, catalyzed by the chiral dirhodium(II) complexes. During the course of our research, the absolute configuration of the enantiomer of 4-pheny[1,2,3]oxathiazinane 2,2-dioxide (4r), prepared by the Du Bois asymmetric C-H amination reaction of 3 and the Rh2(S-nap)4 catalyst, is determined to be R and not S as was originally reported.

A chiral rhodium carboxamidate catalyst for enantioselective C-H amination

Rh2(S-nap)4, a chiral dirhodium tetracarboxamidate complex, has been developed and shown to be an effective catalyst for the asymmetric, intramolecular C-H amination of sulfamate esters. Enantiomeric excesses range from 60-99% for a collection of disparately substituted 3-arylpropylsulfamates. In addition, Rh2(S-nap)4 is found to promote chemoselective allylic C-H oxidation of unsaturated sulfamates, a property not observed with other dirhodium complexes tested to date. Copyright

Stereoselective Synthesis and Absolute Stereochemistry of Sinefungin

Sinefungin has been synthesized from D-ribose, L-ornithine, and adenine.L-Ornithine was converted to its δ-nitro analogue 10, which was coupled to the ribose derived aldehyde 11 by a potassium fluoride catalyzed nitro-aldol reaction.The resulting nitro al