1242965-11-2

Basic information

• Product Name: methyl 2,4,6-tri-O-acetyl-3-deoxy-3-(4-(2-fluorophenyl)-1H-[1,2,3]-triazol-1-yl)-1-thio-β-D-galactopyranoside
• Synonyms: methyl 2,4,6-tri-O-acetyl-3-deoxy-3-(4-(2-fluorophenyl)-1H-[1,2,3]-triazol-1-yl)-1-thio-β-D-galactopyranoside
• CAS NO: 1242965-11-2
• Molecular Weight: 481.502
• Mol File: 1242965-11-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2,4,6-tri-O-acetyl-3-deoxy-3-(4-(2-fluorophenyl)-1H-[1,2,3]-triazol-1-yl)-1-thio-β-D-galactopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,4,6-tri-O-acetyl-3-deoxy-3-(4-(2-fluorophenyl)-1H-[1,2,3]-triazol-1-yl)-1-thio-β-D-galactopyranoside(1242965-11-2)
• EPA Substance Registry System: methyl 2,4,6-tri-O-acetyl-3-deoxy-3-(4-(2-fluorophenyl)-1H-[1,2,3]-triazol-1-yl)-1-thio-β-D-galactopyranoside(1242965-11-2)

Safety Data

• Hazardous Substances Data: 1242965-11-2(Hazardous Substances Data)

Upstream product

• 443864-69-5 methyl 2,4,6-tri-O-acetyl-3-azido-3-deoxy-1-thio-β-D-galactospyranoside 
• 766-49-4 (2-fluorophenyl)acetylene 

Relevant articles and documents

1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

Galactose C3-triazole derivatives were synthesized by Cu(I)-catalyzed cycloaddition between acetylenes and galactose C3-azido derivatives. Evaluation against galectin-3, 7, 8N (N-terminal) and 9N (N-terminal) revealed 1,4-disubstituted triazoles to be high-affinity inhibitors of galectin-3 with selectivity over galectin-7, 8N, and 9N. Conformational analysis of 1,4-di- and 1,4,5-tri-substituted galactose C3-triazoles suggested that a triazole C5-substituent interfered sterically with the galectin proteins, which explained their poor affinities compared to the corresponding 1,4-disubstituted triazoles. Introduction of two 1,4-disubstituted triazole moieties onto thiodigalactoside resulted in affinities down to 29 nM for galectin-3.