124300-16-9Relevant academic research and scientific papers
Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones
Kumar,Azim,Kumar,Sharma,Prasad,Howarth,Olsen,Jain,Parmar
, p. 2643 - 2652 (2001)
The chemo- and enantioselective capabilities of porcine pancreatic lipase (PPL) in tetrahydrofuran, and Candida rugosa lipase (CRL) in diisopropyl ether have been investigated for the acetylation of racemic 2-alkyl/aryl-3-hydroxypropiophenones, which are
INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR
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Page/Page column 89-90, (2021/10/11)
Chromanone compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the inhibition of antigen presentation by HLA-DR.
A New Synthesis of 3-Methylchromanones from 2-Hydroxypropiophenones
Jain, Amolak C.,Tyagi, Om D.,Saksena, Rene (nee Shrivastava)
, p. 15 - 20 (2007/10/02)
The reaction of 2-hydroxy-3,4-dimethoxypropiophenone (1b) with ethoxymethyl chloride in the presence of K2CO3 and acetone yields only α-hydroxymethyl derivative (3b), whereas 2-hydroxy-4-methoxypropiophenone (1a) gives 3a and the coupled product 2.Similarly 2,4-dihydroxypropiophenone (5) and 2,3,4-trihydroxypropiophenone (1a) yield the α-hydroxymethyl derivatives (7 and 14) and the coupled products (8 and 13).However, 2-hydroxy-4,6-dimethoxypropiophenone (18) affords only the coupled product (19).Compounds 3a, b on reaction with 2percent aq. ethanolic sodium carbonate give the corresponding 3-methylchromanones (4a and 4b).A similar reaction of 7 and 14 eventually affords the corresponding chromanone (10 and 17) in overall 10percent yields.
