124300-16-9

Basic information

• Product Name: (R,S)-3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-methylpropan-1-one
• Synonyms: (R,S)-3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-methylpropan-1-one
• CAS NO: 124300-16-9
• Molecular Weight: 210.23
• Mol File: 124300-16-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R,S)-3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-methylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-methylpropan-1-one(124300-16-9)
• EPA Substance Registry System: (R,S)-3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-methylpropan-1-one(124300-16-9)

Safety Data

• Hazardous Substances Data: 124300-16-9(Hazardous Substances Data)

Upstream product

• 6270-44-6 2-hydroxy-4-methoxypropiophenone 
• 3188-13-4 ethyl chloromethyl ether 
• 50-00-0 formaldehyd 

Downstream Products

• 124300-15-8 bis(4-hydroxy-2-methoxy-5-propionylphenyl)-methane 
• 54031-59-3 7-methoxy-3-methylchroman-4-one 
• 6270-44-6 2-hydroxy-4-methoxypropiophenone 

Relevant articles and documents

Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones

The chemo- and enantioselective capabilities of porcine pancreatic lipase (PPL) in tetrahydrofuran, and Candida rugosa lipase (CRL) in diisopropyl ether have been investigated for the acetylation of racemic 2-alkyl/aryl-3-hydroxypropiophenones, which are

A New Synthesis of 3-Methylchromanones from 2-Hydroxypropiophenones

The reaction of 2-hydroxy-3,4-dimethoxypropiophenone (1b) with ethoxymethyl chloride in the presence of K2CO3 and acetone yields only α-hydroxymethyl derivative (3b), whereas 2-hydroxy-4-methoxypropiophenone (1a) gives 3a and the coupled product 2.Similarly 2,4-dihydroxypropiophenone (5) and 2,3,4-trihydroxypropiophenone (1a) yield the α-hydroxymethyl derivatives (7 and 14) and the coupled products (8 and 13).However, 2-hydroxy-4,6-dimethoxypropiophenone (18) affords only the coupled product (19).Compounds 3a, b on reaction with 2percent aq. ethanolic sodium carbonate give the corresponding 3-methylchromanones (4a and 4b).A similar reaction of 7 and 14 eventually affords the corresponding chromanone (10 and 17) in overall 10percent yields.