124309-70-2

Upstream product

• 62484-14-4 8-methoxyquinazoline-2,4-diol 

Downstream Products

• 1542704-70-0 N-benzyl-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-8-(2-methoxyethoxy)quinazolin-4-amine 
• 1542705-32-7 N-benzyl-8-(2-methoxyethoxy)-2-(2-methyl-1H-benzo[d]imidazol-1-yl)quinazolin-4-amine 

Relevant academic research and scientific papers

MONO AND BICYCLIC RING BORONIC ACID, ESTER AND SALT COMPOUNDS AS INHIBITORS OF P97 COMPLEX

Monocyclic or bicyclic ring boronic acid or ester compounds having an arylalkyi amine substituent at the 4 position and a substituted 5:6 bicyclic group at the 2 position of the mono or bicyclic ring boronic acid or ester as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the mono or bicyclic boronic acid or ester compounds are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with the Valosin containing protein and p97 bioactivity such as cancer. Formula (I).

Quinazoline derivatives

Compounds of structure (I): in which, , R1 to R4 are the same or different and are each hydrogen, C1 4alkyl, C1 4alkoxy, phenyl, C1 4alkylthio, C1 4alkanoyl