1243143-45-4

Basic information

• Product Name: 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoroMethyl-phenol
• Synonyms: 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoroMethyl-phenol;4-Hydroxy-3-trifluoromethylphenylboronic acid pinacol ester
• CAS NO: 1243143-45-4
• Molecular Formula: C₁₃H₁₆BF₃O₃
• Molecular Weight: 288.0705496
• Mol File: 1243143-45-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoroMethyl-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoroMethyl-phenol(1243143-45-4)
• EPA Substance Registry System: 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoroMethyl-phenol(1243143-45-4)

Safety Data

• Hazardous Substances Data: 1243143-45-4(Hazardous Substances Data)

Usage

General Description

4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoroMethyl-phenol is a chemical compound with a complex molecular structure. It contains a phenol group with a trifluoromethyl substituent, as well as a boron-containing heterocycle. The compound also has four methyl groups attached to the boron atom, which further adds to its steric bulk. This chemical may have potential applications in organic synthesis, pharmaceuticals, and materials science due to its unique structure and reactivity. It could be used as a reagent in Suzuki-Miyaura cross-coupling reactions or in the development of new drugs or materials. However, it is important to handle this compound with caution, as boron-containing compounds can be toxic and have specific handling requirements in the laboratory.

Upstream product

• 444-30-4 2-(trifluoromethyl)phenol 
• 73183-34-3 bis(pinacol)diborane 
• 50824-04-9 4-bromo-2-(trifluoromethyl)phenol 

Downstream Products

• 1256944-85-0 (S)-3-(4-hydroxy-3-trifluoromethyl-phenyl)-cyclopentanone 

Relevant articles and documents

Building blocks for recognition-encoded oligoesters that form H-bonded duplexes

Competition from intramolecular folding is a major challenge in the design of synthetic oligomers that form intermolecular duplexes in a sequence-selective manner. One strategy is to use very rigid backbones that prevent folding, but this design can preju

Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation

The selective functionalization of C-H bonds at the arene para position is highly challenging using transition metal catalysis. Iridium-catalyzed borylation has emerged as a leading technique for arene functionalization, but there are only a handful of strategies for para-selective borylation, which operate on specific substrate classes and use bespoke ligands or catalysts. We describe a remarkably general protocol which results in para-selectivity on some of the most common arene building blocks (anilines, benzylamines, phenols, benzyl alcohols) and uses standard borylation ligands. Our strategy hinges upon the facile conversion of the substrates into sulfate or sulfamate salts, wherein the anionic arene component is paired with a tetrabutylammonium cation. We hypothesize that the bulk of this cation disfavors meta-C-H borylation, thereby promoting the challenging para-selective reaction.

BIARYL DERIVATIVES AS GPR120 AGONISTS

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