1243153-58-3Relevant academic research and scientific papers
A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity
Urgaonkar, Sameer,Cortese, Joseph F.,Barker, Robert H.,Cromwell, Mandy,Serrano, Adelfa E.,Wirth, Dyann F.,Clardy, Jon,Mazitschek, Ralph
supporting information; experimental part, p. 3998 - 4001 (2010/10/21)
The development of a concise strategy to access 2-amino-3-hydroxy-indoles, which are disclosed as novel antimalarials with potent in vivo activity, is reported. Starting from isatins the target compounds are synthesized in 2 steps and in good yields via oxoindole intermediates by employing tert- butyldimethylsilyl amine (TBDMSNH2) as previously unexplored ammonia equivalent.
