1243154-19-9Relevant academic research and scientific papers
An effective BINAP and microwave accelerated palladium-catalyzed amination of 1-chloroisoquinolines in the synthesis of new 1,3-disubstituted isoquinolines
Prabakaran,Manivel,Nawaz Khan
experimental part, p. 4340 - 4343 (2010/09/20)
A facile and microwave accelerated reaction of 1-chloro-3-(4-chlorophenyl) isoquinoline with various heterocyclic amines, catalyzed by Pd, in the presence of BINAP additive and sodium carbonate as the base, leads to the formation of 3-(4-chlorophenyl)-1-(1H-1,2,3-triazol-1-yl)isoquinoline, 3-(4-chlorophenyl)-1- (1H-imidazol-1-yl)isoquinoline and 3-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl) isoquinoline via Buchwald protocol in good yields. Similarly pyrazolylisoquinolines are also reported.
