124319-51-3Relevant academic research and scientific papers
Pyrrole butyric acid derivatives as inhibitors of steroid 5α- reductase
Kato, Masaya,Komoda, Keiko,Namera, Akira,Sarai, Yusuke,Okada, Satoshi,Yamada, Akira,Yokoyama, Kouichi,Migita, Emiko,Minobe, Yasushi,Tani, Tadato
, p. 1767 - 1776 (2007/10/03)
A series of pyrrole butyric acid derivatives was synthesized and evaluated for inhibitory activity on human and rat steroid 5α-reductase in vitro and ex vivo. 3-Benzoyl-4-alkylpyrrole-1-butyric acids and 1-methyl- 2-alkyl-3-benzoylpyrrole-5-butyric acid derivatives were effective inhibitors. Structure activity relationships were evaluated among the 37 compounds synthesized. Compound 37 (HQL-1069) shows potent inhibitory activities against both rat and human 5α-reductase.
Small peptide inhibitors of smooth muscle myosin light chain kinase
Gaeta,Lehman De Gaeta,Kogan,Or,Foster,Czarniecki
, p. 964 - 972 (2007/10/02)
The pentapeptide Ser-Asn-Val-Phe-Ala-OBzl has been identified as the smallest inhibitory peptide of myosin light chain kinase (MLCK) derived from the primary sequence of the light chain phosphorylation site. The specific contributions of individual amino
