1243245-69-3

Usage

Uses

Used in Pharmaceutical Research:
[4-(2-Methyl-pyridin-4-yl)-phenyl]-acetic acid is used as a research compound for its potential therapeutic applications. Its structural properties, including the presence of a substituted pyridine ring, make it a promising candidate for the development of new drugs.
Used in Anti-inflammatory and Analgesic Drug Development:
In the field of drug development, [4-(2-Methyl-pyridin-4-yl)-phenyl]-acetic acid is utilized as a lead compound for the creation of anti-inflammatory and analgesic medications. Studies have indicated that derivatives of phenylacetic acid, including [4-(2-Methyl-pyridin-4-yl)-phenyl]-acetic acid, have demonstrated anti-inflammatory and analgesic effects, which are valuable for treating various conditions associated with pain and inflammation.
Further research is necessary to fully understand the potential uses and benefits of [4-(2-Methyl-pyridin-4-yl)-phenyl]-acetic acid, as its therapeutic applications are still being investigated. As it stands, the compound holds promise for contributing to advancements in pharmaceuticals, particularly in the areas of pain management and inflammation control.

Upstream product

• 1243245-68-2 ethyl 2-(4-(2-methylpyridin-4-yl)phenyl)acetate 
• 660867-80-1 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 22282-99-1 4-bromo-2-methylpyridine 
• 14062-25-0 Ethyl 4-bromophenylacetate 

Downstream Products

• 1243244-02-1 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(6-morpholinopyridin-3-yl)acetamide 
• 1243245-75-1 N-(5-iodopyridin-2-yl)-2-(4-(2-methylpyridin-4-yl)phenyl)acetamide 
• 1243244-51-0 tert-butyl 4-(6-(2-(4-(2-methylpyridin-4-yl)phenyl)acetamido)pyridin-3-yl)piperazine-1-carboxylate 
• 1243243-57-3 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(5-phenylpyridin-2-yl)acetamide 
• 1243244-69-0 N-(5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-2-(4-(2-methylpyridin-4-yl)phenyl)acetamide 
• 1243244-67-8 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(5-(3-oxopiperazin-1-yl)pyridin-2-yl)acetamide 

Relevant academic research and scientific papers

With Wnt signal path to inhibit the active heterocyclic compounds (by machine translation)

The invention relates to a signal path with Wnt inhibiting activity of a heterocyclic compound, including the compound and its pharmaceutically acceptable salt, various isotope, various isomers or various crystal structure, having the general formula I of the structure shown in: the invention relates to a compound and its joint application composition can effectively inhibit the Wnt signal path, can be used for the treatment or prevention of a disorder associated with a Wnt signal path. (by machine translation)

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system

The Wnt signaling pathway is a critical developmental pathway which operates through control of cellular functions such as proliferation and differentiation. Aberrant Wnt signaling has been linked to the formation and metastasis of tumors. Porcupine, a member of the membrane-bound O-acyltransferase family of proteins, is an important component of the Wnt pathway. Porcupine catalyzes the palmitoylation of Wnt proteins, a process needed for their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from a known porcupine inhibitor class. The leading compound 59 demonstrated subnanomolar inhibition of Wnt signaling in a paracrine cellular assay. Compound 59 also showed excellent chemical, plasma and liver microsomal stabilities. Furthermore, compound 59 exhibited good pharmacokinetic profiles with 30% oral bioavailability in rat. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.

N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS

The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A1, A2, B, Y and Z all represent rings.