1243279-74-4Relevant articles and documents
NOVEL THYROMIMETICS
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Page/Page column 152, (2021/06/04)
Compounds are provided having the structure of Formula (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R2, X1, X2, Y1, and Y2 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
The synthesis and antimicrobial activity of heterocyclic derivatives of totarol
Kim, Michelle B.,O'Brien, Terrence E.,Moore, Jared T.,Anderson, David E.,Foss, Marie H.,Weibel, Douglas B.,Ames, James B.,Shaw, Jared T.
supporting information, p. 818 - 822 (2013/01/15)
The synthesis and antimicrobial activity of heterocyclic analogues of the diterpenoid totarol are described. An advanced synthetic intermediate with a ketone on the A-ring is used to attach fused heterocycles, and a carbon-to-nitrogen atom replacement is made on the B-ring by de novo synthesis. A-ring analogues with an indole attached exhibit, for the first time, enhanced antimicrobial activity relative to the parent natural product. Preliminary experiments demonstrate that the indole analogues do not target the bacterial cell division protein FtsZ as had been hypothesized for totarol.
