1243322-19-1Relevant academic research and scientific papers
Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases
Fuchs, Michael,Koszelewski, Dominik,Tauber, Katharina,Kroutil, Wolfgang,Faber, Kurt
supporting information; experimental part, p. 5500 - 5502 (2010/10/19)
A straightforward, high-yielding, chemoenzymatic total synthesis of enantiopure (S)-Rivastigmine was developed using various ω-transaminases for the asymmetric amination of appropriate acetophenone precursors. Optimisation of the biotransformation allowed scale-up and the total synthesis of (S)-Rivastigmine. The Royal Society of Chemistry 2010.
