1243373-36-5Relevant academic research and scientific papers
Methylene amine substituted arylindenopyrimidines as potent adenosine A2A/A1 antagonists
Shook, Brian C.,Rassnick, Stefanie,Hall, Daniel,Rupert, Kenneth C.,Heintzelman, Geoffrey R.,Hansen, Kristen,Chakravarty, Devraj,Bullington, James L.,Scannevin, Robert H.,Magliaro, Brian,Westover, Lori,Carroll, Karen,Lampron, Lisa,Russell, Ronald,Branum, Shawn,Wells, Kenneth,Damon, Sandra,Youells, Scott,Li, Xun,Osbourne, Mel,Demarest, Keith,Tang, Yuting,Rhodes, Kenneth,Jackson, Paul F.
scheme or table, p. 2864 - 2867 (2010/07/06)
A novel series of arylindenopyrimidines were identified as A2A and A1 receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson's disease when dosed orally.
