124340-93-8Relevant articles and documents
Synthesis and biological evaluation of novel benzimidazole derivatives bearing a heterocyclic ring at 4/5 position
Wubulikasimu, Reyila,Yang, Yanbing,Xue, Fei,Luo, Xianjin,Shao, Dongping,Li, Yuhuan,Gao, Rongmei,Ye, Weidong
, p. 2297 - 2304 (2013/09/24)
A series of novel benzimidazole derivatives bearing a heterocyclic ring as oxadiazole (21-32), thiadiazole (33-34), triazole (35-36) were synthesized and evaluated for their activities against Coxsackie virus B3 and B6 in Vero cells. Compounds 21-26, 31-36 with moieties of 2'-pyridyl, 3'-pyridyl and 4'-pyridyl at the 2-position and oxadiazoles, thiadiazole, or triazole substituent at the 4- or 5-position generally displayed activities against CVB3 and CVB6. Especially compound 24 (IC50 = 1.08 μg/mL, SI = 61.7 against CVB3) was the promising candidate as lead compound for anti-enteroviral drug. It was observed in the incorporation of heterocyclic rings in benzimidazole at the 5-position could enhance their biological activities.
Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives
Cheng, Jun,Xie, Jiangtao,Luo, Xianjin
, p. 267 - 269 (2007/10/03)
Some benzimidazole derivatives were synthesized and the antiviral evaluation against Coxsackie virus B3 is reported. These compounds are proved to be excellent inhibitors of CVB3. Some benzimidazole derivatives were synthesized and evaluated for their antiviral properties. Compounds 20 and 21 showed potent selective activity against Coxsackie virus B3 in VERO cells. Some structure-activity relationships were discussed.
Substituted benzimidazoles
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, (2008/06/13)
Compounds of formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.