N-Hydroxysertraline is a significant metabolite of Sertraline (S280000), which is a potent and selective inhibitor of neuronal serotonin uptake. It plays a crucial role in the pharmacological effects of Sertraline, contributing to its overall efficacy in treating various conditions related to serotonin regulation.
124345-07-9
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Basic information
- Product Name: N-Hydroxysertraline
- Synonyms: (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-hydroxy-N-Methyl-1-naphthalenaMine;N-Hydroxy Sertraline;N-Hydroxysertraline
- CAS NO:124345-07-9
- Molecular Formula: C17H17Cl2NO
- Molecular Weight: 322.22898
- EINECS: N/A
- Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File: 124345-07-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 458.3±45.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.34±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: -20°C Freezer, Under inert atmosphere
- Solubility: DMSO (Slightly), Ethyl Acetate (Sparingly)
- PKA: 13.17±0.40(Predicted)
- CAS DataBase Reference: N-Hydroxysertraline(CAS DataBase Reference)
- NIST Chemistry Reference: N-Hydroxysertraline(124345-07-9)
- EPA Substance Registry System: N-Hydroxysertraline(124345-07-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 124345-07-9(Hazardous Substances Data)
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124345-07-9 Usage
Uses
Used in Pharmaceutical Industry:N-Hydroxysertraline is used as an active metabolite for enhancing the therapeutic effects of Sertraline. It contributes to the overall efficacy of Sertraline in treating conditions such as depression, anxiety, obsessive-compulsive disorder, post-traumatic stress disorder, and premenstrual dysphoric disorder by modulating serotonin levels in the brain.
Used in Research and Development:
N-Hydroxysertraline is used as a research compound for studying the pharmacokinetics, pharmacodynamics, and metabolism of Sertraline. This helps in understanding the drug's mechanism of action, optimizing its dosage, and developing new drugs with improved efficacy and safety profiles.
Used in Drug Metabolism Studies:
N-Hydroxysertraline is used as a reference compound in drug metabolism studies, particularly in the investigation of cytochrome P450 enzymes involved in the metabolism of Sertraline. This aids in the development of personalized medicine approaches and the prediction of drug-drug interactions.
Used in Quality Control and Standardization:
N-Hydroxysertraline is used as a reference standard in the quality control and standardization of Sertraline-containing pharmaceutical products. It ensures the accurate quantification of the active metabolite and helps maintain the consistency, safety, and efficacy of Sertraline medications.
Check Digit Verification of cas no
The CAS Registry Mumber 124345-07-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,3,4 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.Calculate Digit Verification of CAS Registry Number 124345-07:
(8*1)+(7*2)+(6*4)+(5*3)+(4*4)+(3*5)+(2*0)+(1*7)=99
99 % 10 = 9
So 124345-07-9 is a valid CAS Registry Number.
124345-07-9Upstream product
124345-07-9Downstream Products
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N-Hydroxysertraline
