124351-85-5 Usage
Description
Bisphonal, a new third generation drug, was launched in Japan for the
treatment of osteoporosis. It can be prepared in two steps by heating
cycloheptylamine, triethylorthoformate and diethyl phosphite followed by ester
hydrolysis. The mechanism of action is not well understood. Bisphonal has no effect
on bone mineralization but tightly binds to calcified bone matrix and inhibits bone
resorption. It causes a decrease in the number and activity of osteoclasts
(morphology and decrease in H+ secretion). They seem to undergo cell death with an
impairment in the process of osteoclast formation. Bisphonal does not induce
osteomalacia and its activity is partly mediated through osteoblasts (releases an
inhibitor of osteoclast recruitment). It is a potent inhibitor of squalene synthase (50-fold) maybe by Mg2+ chelation or as a pyrophosphate mimic, undergoes practically no
metabolism, and stimulates renal production of 1,25-dihydroxyvitamin D.
Originator
Yamanouchi (Japan)
Uses
Incandronate is a bisphosphonate derivative. Bisphosphonates are most widely used as agents for treating osteoporosis and have also been used for other purposes such as herbicides, anticancer agents, and antiparasitics.
Brand name
Bisphonal
Check Digit Verification of cas no
The CAS Registry Mumber 124351-85-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,3,5 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 124351-85:
(8*1)+(7*2)+(6*4)+(5*3)+(4*5)+(3*1)+(2*8)+(1*5)=105
105 % 10 = 5
So 124351-85-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H19NO6P2/c10-16(11,12)8(17(13,14)15)9-7-5-3-1-2-4-6-7/h7-9H,1-6H2,(H2,10,11,12)(H2,13,14,15)
