124355-23-3Relevant academic research and scientific papers
An efficient synthesis of 3′-amino-3′-deoxythymidine derivatives
Seregin,Chudinov,Yurkevich,Shvets
, p. 135 - 138 (2005)
An efficient method of reduction of 3′-azido-3′-deoxythymidine and its 5′-protected derivatives to 3′-aminothymidine derivatives on a palladium catalyst using ammonium formate as a source of hydrogen was suggested.
Synthesis and Antiviral Activity of 3'-Heterocyclic Substituted 3'-Deoxythymidines
Wigerinck, Piet,Aerschot, Arthur Van,Janssen, Gerard,Claes, Paul,Balzarini, Jan,et al.
, p. 868 - 873 (2007/10/02)
Various 3'-deoxythymidine analogues with an heterocyclic five-membered ring in the 3'-erythro position have been synthesized.The pyrrol-1-yl (3) and the 1,2,4-triazol-4-yl (5) compounds were synthesized from 1-(3-amino-2,3-dideoxy-β-D-erythro-pentofuranosyl)thymine.The pyrazol-1-yl (16a), imidazol-1-yl (16b), and 1,2,4-triazol-1-yl (16c) derivatives were obtained by epoxide opening of the corresponding 1-(2,3-anhydro-β-D-lyxofuranosyl)thymines followed by 2'-deoxygenation.Only the 3'-pyrrol-1-yl derivative showed marginal antiviral activity against human immunodeficiency virus.
