124355-25-5

Basic information

• Product Name: 3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine
• Synonyms: 3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine
• CAS NO: 124355-25-5
• Molecular Weight: 483.567
• Mol File: 124355-25-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine(124355-25-5)
• EPA Substance Registry System: 3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine(124355-25-5)

Safety Data

• Hazardous Substances Data: 124355-25-5(Hazardous Substances Data)

Upstream product

• 29706-84-1 1-(3-azido-2,3-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)thymine 
• 7791-71-1 5'-O-tritylthymidine 
• 42214-24-4 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)thymine 
• 25442-42-6 5'-O-trityl-2,3'-anhydrothymidine 
• 55612-11-8 5'-O-trityldeoxyxylothymidine 
• 104218-44-2 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine 
• 76-83-5 trityl chloride 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 

Downstream Products

• 168838-65-1 1-[(2R,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-[(2S,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-thiourea 
• 227084-00-6 1-((E)-3-Ethoxy-acryloyl)-3-[(2S,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-urea 
• 219653-01-7 3'-isothiocyanato-5'-O-trityl-3'-deoxythymidine 
• 1446526-80-2 3'-deoxy-3'-N-[(carboxymethyl)amino]-5'-O-tritylthymidine 
• 1446526-79-9 3'-deoxy-3'-N-[(ethoxycarbonyl)methylamino]-5'-O-tritylthymidine 
• 1271302-36-3 N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-benzylthiourea 
• 1271302-26-1 N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-benzylguanidine 
• 1271302-24-9 N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-guanidine 
• 1271302-21-6 3'-[(3-trifluoromethyl-4-chloro)-benzylamino]-3'-deoxy-β-D-thymidine 
• 1271302-18-1 3'-(4-chlorobenzylamino)-3'-deoxy-β-D-thymidine 
• 1271302-14-7 3'-[(3-trifluoromethyl-4-chloro)-benzylamino]-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine 
• 1271302-12-5 3'-(4-chlorobenzylamino)-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine 
• 1271302-34-1 N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine 
• 1271302-32-9 N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-benzylguanidine 

Relevant articles and documents

An efficient synthesis of 3′-amino-3′-deoxythymidine derivatives

An efficient method of reduction of 3′-azido-3′-deoxythymidine and its 5′-protected derivatives to 3′-aminothymidine derivatives on a palladium catalyst using ammonium formate as a source of hydrogen was suggested.

Uracil- and thymine-substituted thymidine and uridine derivatives

The four possible 3'-uracil-1-yl and 3'-thymin-1-yl derivatives of 3'- deoxythymidine and the four analogous derivatives of 2'-deoxyuridine have been synthesised from thymidine and uridine, respectively. Advantages of the 2-(methoxycarbonyl)vinyl group to prevent the formation of anhydronucleosides and SnCl2/PhSH/Et3N in relation to H2/Pd for the reduction of most azido groups are disclosed.

Synthesis of Thymidine Dimers Containing Internucleoside Sulfonate and Sulfonamide Linkages

Novel chemistry is reported for the formation of internucleoside sulfonate and sulfonamide linkages.