124355-31-3

Basic information

• Product Name: 1-[3-deoxy-3-(1H-imidazol-1-yl)-beta-D-arabinofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 1-(3-Imidazol-1-yl-3-deoxy-.beta.-D-arabinofuranosyl)thymine; 1-(3-Imidazol-1-yl-3-deoxy-beta-D-arabinofuranosyl)thymine
• CAS NO: 124355-31-3
• Molecular Formula: C₁₃H₁₆N₄O₅
• Molecular Weight: 308.2899
• Mol File: 124355-31-3.mol
• Article Data: 1

Chemical Properties

• Density: 1.69g/cm³
• Refractive Index: 1.739
• CAS DataBase Reference: 1-[3-deoxy-3-(1H-imidazol-1-yl)-beta-D-arabinofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-deoxy-3-(1H-imidazol-1-yl)-beta-D-arabinofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione(124355-31-3)
• EPA Substance Registry System: 1-[3-deoxy-3-(1H-imidazol-1-yl)-beta-D-arabinofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione(124355-31-3)

Safety Data

• Hazardous Substances Data: 124355-31-3(Hazardous Substances Data)

Upstream product

• 115913-84-3 1-(2,3-epoxy-5-O-trityl-β-D-lyxo-pentofuranosyl)thymine 
• 124355-30-2 1-(5-O-trityl-3-imidazol-1-yl-3-deoxy-β-D-arabinofuranosyl)thymine 

Relevant articles and documents

Synthesis and Antiviral Activity of 3'-Heterocyclic Substituted 3'-Deoxythymidines

Various 3'-deoxythymidine analogues with an heterocyclic five-membered ring in the 3'-erythro position have been synthesized.The pyrrol-1-yl (3) and the 1,2,4-triazol-4-yl (5) compounds were synthesized from 1-(3-amino-2,3-dideoxy-β-D-erythro-pentofuranosyl)thymine.The pyrazol-1-yl (16a), imidazol-1-yl (16b), and 1,2,4-triazol-1-yl (16c) derivatives were obtained by epoxide opening of the corresponding 1-(2,3-anhydro-β-D-lyxofuranosyl)thymines followed by 2'-deoxygenation.Only the 3'-pyrrol-1-yl derivative showed marginal antiviral activity against human immunodeficiency virus.