1243560-87-3Relevant academic research and scientific papers
Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation
Vijaya Bhaskar Reddy,Tsai, Wei-Jern,Qian, Keduo,Lee, Kuo-Hsiung,Wu, Tian-Shung
, p. 7711 - 7719 (2012/01/02)
In an effort to develop potent antiplatelet agents, 12 O-prenylated (2-13) and 10 O-allylated (14-23) chalcones were synthesized and screened for in vitro inhibitory effects on aggregation of washed rabbit platelets induced by ADP (20 μM) and collagen (10
Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors
Reddy, Nimmanapalli P.,Aparoy, Polamarasetty,Reddy, T. Chandra Mohan,Achari, Chandrani,Sridhar, P. Ramu,Reddanna, Pallu
experimental part, p. 5807 - 5815 (2010/10/02)
Ten novel mono- and di-O-prenylated chalcone derivatives were designed on the basis of a homology derived molecular model of 5-lipoxygenase (5-LOX). The compounds were docked into 5-LOX active site and the binding characteristics were quantified using LUD
