1243560-97-5Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors
Reddy, Nimmanapalli P.,Aparoy, Polamarasetty,Reddy, T. Chandra Mohan,Achari, Chandrani,Sridhar, P. Ramu,Reddanna, Pallu
, p. 5807 - 5815 (2010)
Ten novel mono- and di-O-prenylated chalcone derivatives were designed on the basis of a homology derived molecular model of 5-lipoxygenase (5-LOX). The compounds were docked into 5-LOX active site and the binding characteristics were quantified using LUD
