1243631-06-2Relevant academic research and scientific papers
High-throughput screening of the asymmetric decarboxylative alkylation reaction of enolate-stabilized enol carbonates
McDougal, Nolan T.,Virgil, Scott C.,Stoltz, Brian M.
, p. 1712 - 1716 (2010)
The use of high-throughput screening allowed for the optimization of reaction conditions for the palladium-catalyzed asymmetric decarboxylative alkylation reaction of enolate-stabilized enol carbonates. Changing to a nonpolar reaction solvent and to an electron-deficient PHOX derivative as ligand from our standard reaction conditions improved the enantioselectivity for the alkylation of a ketal-protected,1,3-diketone-derived enol carbonate from 28% ee to 84% ee. Similar improvements in enantioselectivity were seen for a β-keto ester derived and an α-phenyl cyclohexanone-derived enol carbonate. Georg Thieme Verlag Stuttgart New York.
