1243663-64-0Relevant academic research and scientific papers
Construction of quaternary stereogenic carbon centers by the Lewis base catalyzed conjugate addition of silyl ketene imines to α,β- unsaturated aldehydes and ketones
Denmark, Scott E.,Wilson, Tyler W.
, p. 1723 - 1728 (2010)
Highly site-selective Mukaiyama-Michael additions of silyl ketene imines to α,β-unsaturated aldehydes and ketones are described. The combination of silicon tetrachloride and a chiral bisphosphoramide provides an effective catalyst system for promoting the addition of silyl ketene imines to a variety of aromatic enals with high site selectivity and moderate to good diastereo- and enantioselectivity. Georg Thieme Verlag Stuttgart New York.
