1243726-40-0

Basic information

• Product Name: (R)-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate
• Synonyms: (R)-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate
• CAS NO: 1243726-40-0
• Molecular Weight: 291.39
• Mol File: 1243726-40-0.mol

Chemical Properties

• CAS DataBase Reference: (R)-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate(1243726-40-0)
• EPA Substance Registry System: (R)-(+)-tert-butyl 2-(4-methoxybenzyl)pyrrolidine-1-carboxylate(1243726-40-0)

Safety Data

• Hazardous Substances Data: 1243726-40-0(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 202925-92-6 N-Pent-4-enylcarbamic acid tert-butyl ester 
• 104-92-7 1-bromo-4-methoxy-benzene 

Relevant articles and documents

Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis. This journal is

Asymmetric Synthesis and Application of Chiral Spirosilabiindanes

Reported here is the development of a class of chiral spirosilabiindane scaffolds by Rh-catalyzed asymmetric double hydrosilation, for the first time. Enantiopure SPSiOL (spirosilabiindane diol), a new type of chiral building block for the preparation of various chiral ligands and catalysts, was readily prepared on greater than 10 gram scale using this protocol. The potential of this new spirosilabiindane scaffold in asymmetric catalysis was preliminarily demonstrated by development of the corresponding monodentate phosphoramidite ligands (SPSiPhos), which were used in both a Rh-catalyzed hydrogenation and a Pd-catalyzed intramolecular carboamination.

Asymmetric palladium-catalyzed carboamination reactions for the synthesis of enantiomerically enriched 2-(Arylmethyl)- and 2-(Alkenylmethyl)pyrrolidines

The enantioselective synthesis of 2-(arylmethyl)- and 2-(alkenylmethyl) pyrrolidine derivatives via Pd-catalyzed alkene carboamination reactions is described. These transformations generate enantiomerically enriched products with up to 94% ee from readily