124392-37-6

Basic information

• Product Name: 2-((4-CHLOROPHENYL)SULFONYL)-3,3-DIMETHYLTHIOPROP-2-ENENITRILE
• Synonyms: 2-((4-CHLOROPHENYL)SULFONYL)-3,3-DIMETHYLTHIOPROP-2-ENENITRILE
• CAS NO: 124392-37-6
• Molecular Formula: C₁₁H₁₀ClNO₂S₃
• Molecular Weight: 319.85
• Mol File: 124392-37-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-((4-CHLOROPHENYL)SULFONYL)-3,3-DIMETHYLTHIOPROP-2-ENENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-CHLOROPHENYL)SULFONYL)-3,3-DIMETHYLTHIOPROP-2-ENENITRILE(124392-37-6)
• EPA Substance Registry System: 2-((4-CHLOROPHENYL)SULFONYL)-3,3-DIMETHYLTHIOPROP-2-ENENITRILE(124392-37-6)

Safety Data

• Hazardous Substances Data: 124392-37-6(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 1851-09-8 2-(4-chlorobenzenesulfonyl)acetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 124392-30-9 (E)-2-(4-Chloro-benzenesulfonyl)-3-(2-methoxy-phenylamino)-3-methylsulfanyl-acrylonitrile 
• 124392-50-3 5-(4-Chloro-benzenesulfonyl)-N'-(2-methoxy-phenyl)-pyrimidine-2,4,6-triamine 
• 124392-52-5 5-(4-Chloro-benzenesulfonyl)-N'-(4-ethoxy-phenyl)-pyrimidine-2,4,6-triamine 
• 124392-51-4 2,4-diamino-6-<(4-methoxyphenyl)amino>-5-(4-chlorophenyl)-sulfonylpyrimidine 
• 124392-49-0 5-(4-Chloro-benzenesulfonyl)-N'-o-tolyl-pyrimidine-2,4,6-triamine 
• 124392-48-9 5-(4-Chloro-benzenesulfonyl)-N'-phenyl-pyrimidine-2,4,6-triamine 
• 124392-29-6 (E)-2-(4-Chloro-benzenesulfonyl)-3-methylsulfanyl-3-o-tolylamino-acrylonitrile 
• 124392-32-1 (E)-2-(4-Chloro-benzenesulfonyl)-3-(4-ethoxy-phenylamino)-3-methylsulfanyl-acrylonitrile 
• 124392-28-5 (E)-2-(4-Chloro-benzenesulfonyl)-3-methylsulfanyl-3-phenylamino-acrylonitrile 
• 124392-31-0 (E)-2-(4-Chloro-benzenesulfonyl)-3-(4-methoxy-phenylamino)-3-methylsulfanyl-acrylonitrile 

Relevant articles and documents

Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a] pyrimidin-4-imines as potent 5-HT6 antagonists

Comprehensive structure activity relationship (SAR) studies were conducted on a focused screening hit, 2-(methylthio)-3-(phenylsulfonyl)-4H-pyrido[1,2-a] pyrimidin-4-imine (1, IC50: 4.0 nM), as 5-HT6 selective antagonists. Activity was improved some 2-4 fold when small, electron-donating groups were added to the central core as observed in 19, 20 and 26. Molecular docking of key compounds in a homology model of the human 5-HT6 receptor was used to rationalize our structure-activity relationship (SAR) findings. In pharmacokinetic experiments, compound 1 displayed good brain uptake in rats following intra-peritoneal administration, but limited oral bioavailability.

Imidazolylalkylthioalkylamino-ethylene derivatives

Compounds of the formula STR1 wherein R1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R2 is hydrogen, (lower)alkyl, halogen or hydroxymethyl; m is 1 or 2, and n is 2 or 3, provided that the sum of m and n is 3 or 4; X and Y each are independently hydrogen, nitro, cyano, --SO2 Ar or --COR3, provided that X and Y are not both hydrogen; R3 is (lower)alkyl, Ar, (lower)alkoxy, amino or (lower)-alkylamino; and Ar is an optionally substituted phenyl group; and nontoxic pharmaceutically acceptable acid addition salts thereof, are potent anti-ulcer agents. Processes for their preparation and novel intermediates are also disclosed.