124398-47-6

Upstream product

• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 

Downstream Products

• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 145223-86-5 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-naphthalen-2-yl-ethyl ester 
• 131864-78-3 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-naphthalen-2-yl-ethyl ester 

Relevant academic research and scientific papers

Salts of Mosher's thioacid: agents for determining the enantiomer excess of SN2 substrates

The racemic and the (S)-enantiomer of Mosher's thioacid, 2-methoxy-2-trifluoromethylphenylacetic thioacid, form air-stable salts with Proton Sponge [1,8-bis(dimethylamino)naphthalene]. These salts are powerful nucleophiles that react cleanly (SN2 inversion) in CDCl3 with optically active alkyl halides ranging in reactivities from unactivated alkyl bromides and iodides to benzylic bromides. The diastereomeric excess (de) of the thioester products indicates the enantiomeric excess (ee) of the starting alkyl halides.

Thioacids and thioacid salts for determining the enantiomeric excess of chiral compounds containing an electrophilic carbon center

The invention provides novel chiral compounds including 2-methoxy-2-trifluoromethylphenylacetic thioacid useful to react with and analyze other chiral compounds that have an electrophilic chiral carbon center.