1243985-27-4Relevant academic research and scientific papers
Exploring the scope of the Gewald reaction: Expansion to a four-component process
Abaee, M. Saeed,Hadizadeh, Atefeh,Mojtahedi, Mohammad M.,Halvagar, Mohammad R.
, p. 1408 - 1412 (2017)
An efficient four-component reaction was developed to take advantage of the reactivity of the 2-aminothiophene-3-carbonitrile functionality, which is obtained during the classical three-component Gewald reaction. Various α-methylene bearing ketones were reacted with malononitrile, elemental sulfur, and aryl/heteroarylnitrile derivatives in t-BuOH/NaOH to afford 2-arylthieno[2,3-d]pyrimidin-4-amines in high yields. Preliminary studies revealed the photophysical properties of the products and their potential for use as metal sensors.
Microwave-assisted synthesis of 4-amino-2-arylthieno[2,3- d ]pyrimidines and their subsequent functionalization
Chen, Binbin,Perspicace, Enrico,Hesse, Stephanie,Kirsch, Gilbert
experimental part, p. 2413 - 2418 (2010/09/04)
New 4-amino-2-arylthieno[2,3-d]pyrimidines were synthesized by reacting 2-amino-3-cyanothiophenes and aryl nitriles under microwave irradiation. Functionalization of 4-amino group was made by acetic anhydride and several isocyanates. Georg Thieme Verlag S
