1243989-70-9Relevant academic research and scientific papers
Enantioselective biocatalytic synthesis of (S)-monastrol
Blasco, Maria Alfaro,Thumann, Silvia,Wittmann, Juergen,Giannis, Athanassios,Groeger, Harald
experimental part, p. 4679 - 4682 (2010/10/02)
The first enantioselective biocatalytic synthesis of (S)-monastrol has been developed via an unexpected and unusual enzymatic pathway as suitable route. Whereas attempts for a direct hydrolysis of racemic monastrol were not successful, formation of racemic O-butanoyl monastrol and subsequent enantioselective hydrolysis furnished O-butanoyl (S)-monastrol with 97% ee. Cleavage of the O-butanoyl moiety then gave the desired (S)-monastrol with 96% ee.
