124400-31-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 121-88-0 5-Nitro-2-aminophenol 
• 101084-55-3 2-methylsulfanyl-6-nitro-benzooxazole 
• 7569-26-8 chloromethyl p-tolylsulfone 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 124400-32-4 N-(tert-Butyloxycarbonyl)-O-benzyl-2-amino-5-nitrophenol 
• 1093800-27-1 C₂HF₃O₂*C₂₈H₃₁N₇O₅ 
• 1093795-23-3 C₂₈H₂₉N₇O₄ 
• 1093799-43-9 C₂HF₃O₂*C₁₂H₁₆N₂O₅ 
• 1093799-46-2 C₁₇H₁₈N₂O₄*ClH 
• 1093799-44-0 C₁₉H₂₀N₂O₆ 
• 1093799-45-1 C₁₉H₂₂N₂O₄ 
• 911365-00-9 2-methoxy-4-nitrophenylcarbamic acid tert-butyl ester 
• 124400-58-4 N⁵,1-Dibenzoyl-N⁵-(phenylsulfonyl)-5-amino-6-(benzyloxy)-2-methylindole-3-carboxylic Acid Methyl Ester 
• 124400-54-0 N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol 
• 124400-40-4 N⁵,1-Dibenzoyl-N⁵-(phenylsulfonyl)-5-amino-6-(benzyloxy)-3-methylindole 
• 124400-55-1 N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1-(methoxycarbonyl)-2-oxopropyl)phenol 
• 124400-57-3 N⁵-(Phenylsulfonyl)-5-amino-1-benzoyl-6-(benzyloxy)-2-methylindole-3-carboxylic Acid Methyl Ester 
• 124400-56-2 N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-morpholylphenol 

Relevant academic research and scientific papers

Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors

Human DNA topoisomerase II is one of the major targets in anticancer therapy, however ATP-competitive inhibitors of this target have not yet reached their full potential. ATPase domain of human DNA topoisomerase II belongs to the GHKL ATPase superfamily and shares a very high 3D structural similarity with other superfamily members, including bacterial topoisomerases. In this work we report the discovery of a new chemotype of ATP-competitive inhibitors of human DNA topoisomerase IIα that were discovered through screening of in-house library of ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV. Systematic screening of this library provided us with 20 hit compounds. 1,2,4-Substituted N-phenylpyrrolamides were selected for a further exploration which resulted in 13 new analogues, including 52 with potent activity in relaxation assay (IC50 = 3.2 μM) and ATPase assay (IC50 = 0.43 μM). Cytotoxic activity of all hits was determined in MCF-7 cancer cell line and the most potent compounds, 16 and 20, showed an IC50 value of 8.7 and 8.2 μM, respectively.

The vicarious nucleophilic substitution of hydrogen and related reactions in nitrobenzoxazoles

5- and 6-nitrobenzoxazoles 3 and 4 react with nucleophiles exclusively at C-2, giving ring opening products. If position 2- is blocked with phenyl substituent the reaction takes place in the carbocyclic ring affording the VNS products. 2-Methylthio-5-nitrobenzoxazole 7 and its 6-nitro isomer 8 give products which result from addition of a nucleophile to the carbocyclic ring (VNS) as well as to the heterocyclic ring (S(N)Ar and ring cleavage). 2-Methylthiobenzoxazoles can be readily converted to the corresponding benzoxazolones via oxidative hydrolysis.