1244016-76-9

Upstream product

• 63697-96-1 4-Ethynylbenzaldehyde 
• 73852-88-7 2-(4-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1122-91-4 4-bromo-benzaldehyde 
• 77123-57-0 4-[(trimethylsilyl)ethynyl]bezaldehyde 

Downstream Products

• 1244016-77-0 4-(4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethynyl)benzyl)morpholine 

Relevant academic research and scientific papers

Imidazole as a donor/acceptor unit in charge-transfer chromophores with extended π-linkers

Eleven new, stable, push-pull systems that feature 4,5-bis[4-(N,N- dimethylamino)phenyl]imidazole and 4,5-dicyanoimidazole as the donor and acceptor moieties and the systematically extended and varied π-linker were prepared and investigated. Evaluation of the measured UV/Vis spectra, electrochemical data (cyclic voltammetry (CV), rotating-disc voltammetry (RDV), and polarography) and calculated β and γ polarizabilities showed efficient charge transfer (CT) in biimidazole-type chromophores. Push-pull system 27, which features a planar thiophene-derived π-linker, was revealed to be the most efficient chromophore within the studied series. This chromophore possessed the most bathochromically shifted CT band, the lowest electrochemical gap, and highest β and γ polarizabilities. The CT transition was most significantly affected by structural features such as π-linker length, planarity, conjugating arrangement, and the presence of olefinic/acetylenic or 1,4-phenylene/thiophene subunits in the π-linker. Copyright

HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS

The invention relates to chemical compounds of formula (IB): or a salt thereof. In some embodiments, the invention relates to inhibitors of UDP-3-0 — (R-S-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC). In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein and their use in the prevention and/or treatment of Gram- negative bacterial infections.