1244022-55-6

Usage

Uses

Used in Pharmaceutical Industry:
C₁₅H₂₄N₅O₈P is used as an anti-HIV agent for its antiviral properties. As an impurity of Tenofovir, it contributes to the overall effectiveness of the drug in combating the Human Immunodeficiency Virus (HIV). The compound's reverse transcriptase inhibitor function aids in preventing the virus from replicating, thus helping to manage and treat HIV infections.

Upstream product

• 180587-75-1 (R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate 
• 14047-28-0 (R)-9-(2-hydroxypropyl)adenine 
• 66224-66-6 adenine 
• 35180-01-9 chloromethyl isopropyl carbonate 
• 147127-20-6 tenofovir 

Relevant academic research and scientific papers

Process improvements for the manufacture of tenofovir disoproxil fumarate at commercial scale

The three-step manufacturing process used in the synthesis of tenofovir disoproxil fumarate (1) was studied and optimized, leading to a more productive and robust process. The yield was improved from about 13% overall to 24%. Key process improvements identified included implementation of a telescoped process for the second stage that obviated the need for an extraction and solvent exchange, and significant optimization of the final reaction, including the beneficial effect of adding a quaternary ammonium salt to the alkylation reaction and development of a nonaqueous process for removal of NMP and triethylamine from the product mixture to decrease the level of decomposition of product during the isolation.