1244024-78-9Relevant articles and documents
Organocatalytic and electrophilic approach to oxindoles with C3-quaternary stereocenters
Peng, Jing,Huang, Xin,Cui, Hai-Lei,Chen, Ying-Chun
, p. 4260 - 4263 (2010)
Figure Presented. A Lewis base-catalyzed asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates derived from isatins has been investigated, which provides an electrophilic pathway to access oxindoles bearing C3-quaternary stereocenters. Excellent diastereoselectivity and high enantioselectivity have been obtained in the vinylogous functionalization of α,α-dicyanoolefin nucleophiles, giving multifunctional products with vicinal quaternary and tertiary chiral carbon centers.