1244028-26-9Relevant academic research and scientific papers
One-pot thioether formation from S -nitrosothiols
Zhang, Dehui,Devarie-Baez, Nelmi O.,Pan, Jia,Wang, Hua,Xian, Ming
supporting information; experimental part, p. 5674 - 5676 (2011/02/27)
Protein S-nitrosation is an important post-translational modification. However, the detection of S-nitrosation is still problematic because S-nitrosation products, that is, S-nitrosothiols, are unstable species. Here a new reaction which can selectively c
Reductive ligation mediated one-step disulfide formation of S -nitrosothiols
Zhang, Jiming,Li, Sheng,Zhang, Dehui,Wang, Hua,Whorton, A. Richard,Xian, Ming
supporting information; experimental part, p. 4208 - 4211 (2010/11/17)
A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.
