1244029-73-9Relevant academic research and scientific papers
Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones
Power, David P.,Lozach, Olivier,Meijer, Laurent,Grayson, David H.,Connon, Stephen J.
, p. 4940 - 4944 (2010)
A remarkably concise, chromatography-free route to the parent compound of the paullone family of cyclin-dependent kinase (CDK) inhibitors is reported. A similar strategy allowed the synthesis of the hitherto missing 9-azapaullone and its protonated, N-oxidised and N-alkylated derivatives. Screening studies identified an active and strongly selective inhibitor of CDK9/cyclin T.
