1244030-58-7Relevant academic research and scientific papers
A one-pot approach to 4,5-dihydropyrazoles from ketones, arylacetylenes, and hydrazines
Wang, Ying-Chun,Wang, Heng-Shan,Huang, Guo-Bao,Huang, Fu-Ping,Hu, Kun,Pan, Ying-Ming
, p. 1621 - 1628 (2014)
An efficient and straightforward one-pot strategy for the synthesis of 4,5-dihydropyrazole derivatives from ketones, arylacetylenes, and hydrazines in the presence of KOtBu/DMSO is described. This strategy provides a flexible and rapid route to polysubstituted 4,5-dihydropyrazoles.
Retrosynthetic Analysis of α-Alkenyl-β-Diketones: Regio-and Stereoselective Two-Step Synthesis of Highly Arylated Representatives from Acetylenes, Ketones, and Acyl Chlorides
Shabalin, Dmitrii A.,Ivanova, Elena V.,Ushakov, Igor' A.,Schmidt, Elena Yu.,Trofimov, Boris A.
, p. 8429 - 8436 (2020/07/16)
Highly arylated α-alkenyl-β-diketones are synthesized via a two-step sequence consisting of (i) potassium tert-butoxide/DMSO-catalyzed (E)-stereoselective C-H functionalization of ketones with acetylenes followed by (ii) magnesium bromide etherate/DIPEA-soft enolization of the formed β,γ-unsaturated ketones and regioselective acylation with acyl chlorides. The method is compatible with a broad range of substrates and shown to be applicable as an intermediate stage in the construction of polyarylated heterocycles.
A sequential synthesis of substituted furans from aryl alkynes and ketones involving a cerium(IV) ammonium nitrate (CAN)-mediated oxidative cyclization
Undeela, Sridhar,Ramchandra, Joshi P.,Menon, Rajeev S.
supporting information, p. 5667 - 5670 (2014/12/12)
A convenient, two-step synthesis of substituted furans from readily available aryl alkynes and ketones is reported. The furan-forming oxidative cyclization is mediated by the combination of cerium(IV) ammonium nitrate and potassium bromide and can be carried out in an open flask.
A one-pot approach to Δ2-isoxazolines from ketones and arylacetylenes
Schmidt, Elena Yu.,Tatarinova, Inna V.,Ivanova, Elena V.,Zorina, Nadezhda V.,Ushakov, Igor A.,Trofimov, Boris A.
supporting information, p. 104 - 107 (2013/03/28)
The sequential reaction of ketones with arylacetylenes and hydroxylamine in the presence of KOBut/DMSO followed by the treatment of the reaction mixture with H2O and KOH leads to Δ2-isoxazolines in up to 88% yield.
Base-catalyzed stereoselective vinylation of ketones with arylacetylenes: A new C(sp3)-C(sp2) bond-forming reaction
Trofimov, Boris A.,Schmidt, Elena Yu,Ushakov, IgoR'A,Zorina, Nadezhda V.,Skital'Tseva, Elena V.,Protsuk, Nadezhda I.,Mikhaleva, AL'Bina I.
supporting information; experimental part, p. 8516 - 8521 (2010/09/05)
Alkylaryl- and alkylheteroarylketones, including those with condensed aromatic moieties, are readily vinylated with arylacetylenes (KOH/DMSO, 100°C, 1 h) to give regio- and stereoselectively the (E)-β-γ- ethylenic ketones ((E)-3-buten-1-ones) in 61-84% yi
