1244040-09-2Relevant academic research and scientific papers
A mild, copper-catalysed amide deprotection strategy: Use of tert-butyl as a protecting group
Evans, Vikki,Mahon, Mary F.,Webster, Ruth L.
, p. 7593 - 7597 (2014)
Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2is reported. This allows use of the tert-butyl group as an amide protecting group. The methodology is also extended to Boc-deprotection.
Formal nucleophilic substitution of bromocyclopropanes with amides en route to conformationally constrained β-amino acid derivatives
Prosser, Anthony R.,Banning, Joseph E.,Rubina, Marina,Rubin, Michael
supporting information; experimental part, p. 3968 - 3971 (2010/11/02)
A chemo- and diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with secondary amides is described. This method allows for convergent and highly selective synthesis of trans-β-aminocyclopropane carboxylic acid derivatives.
