1244044-99-2

Basic information

• Product Name: C₁₅H₁₇N
• Synonyms: C₁₅H₁₇N
• CAS NO: 1244044-99-2
• Molecular Weight: 211.307
• Mol File: 1244044-99-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₇N(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₇N(1244044-99-2)
• EPA Substance Registry System: C₁₅H₁₇N(1244044-99-2)

Safety Data

• Hazardous Substances Data: 1244044-99-2(Hazardous Substances Data)

Upstream product

• 1244044-85-6 N-cyclohexyl-4-ethynylbenzamide 

Relevant articles and documents

Controlled and chemoselective reduction of secondary amides

This communication describes a metal-free methodology involving an efficient and controlled reduction of secondary amides to imines, aldehydes, and amines in good to excellent yields under ambient pressure and temperature. The process includes a chemoselective activation of a secondary amide with triflic anhydride in the presence of 2-fluoropyridine. The electrophilic activated amide can then be reduced to the corresponding iminium using triethylsilane, a cheap, rather inert, and commercially available reagent. Imines can be isolated after a basic workup or readily transformed to the aldehydes following an acidic workup. The amine moiety can be accessed via a sequential reductive amination by the addition of silane and Hantzsch ester hydride in a one-pot reaction. Moreover, this reduction tolerates various functional groups that are usually reactive under reductive conditions and is very selective to secondary amides.