16-hydroxyclarithromycin is a metabolite of the antibiotic clarithromycin, which is formed through liver metabolism. It is an active metabolite with antimicrobial properties that can combat a broad spectrum of bacteria, thereby playing a significant role in treating various infections. Characterized by a longer half-life in the body than the parent drug, 16-hydroxyclarithromycin contributes to a sustained therapeutic effect. Extensive research has been conducted on its pharmacokinetics, pharmacodynamics, and potential drug interactions, highlighting its importance in the overall pharmacological profile of clarithromycin.
124412-58-4
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Basic information
- Product Name: 16-hydroxyclarithromycin
- Synonyms: 16-hydroxyclarithromycin
- CAS NO:124412-58-4
- Molecular Formula: C38H69 N O14
- Molecular Weight: 763.95
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 835.8°Cat760mmHg
- Flash Point: 459.3°C
- Appearance: /
- Density: 1.21g/cm3
- Vapor Pressure: 1.95E-32mmHg at 25°C
- Refractive Index: 1.534
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 13.04±0.70(Predicted)
- CAS DataBase Reference: 16-hydroxyclarithromycin(CAS DataBase Reference)
- NIST Chemistry Reference: 16-hydroxyclarithromycin(124412-58-4)
- EPA Substance Registry System: 16-hydroxyclarithromycin(124412-58-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 124412-58-4(Hazardous Substances Data)
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124412-58-4 Usage
Uses
Used in Pharmaceutical Industry:16-hydroxyclarithromycin is used as an antimicrobial agent for its broad-spectrum activity against various bacteria, which is crucial in the treatment of a wide range of infections. Its longer half-life in the body compared to the parent drug clarithromycin enhances its sustained therapeutic effect, making it a valuable component in the effectiveness of the antibiotic.
Used in Research and Development:
In the field of pharmaceutical research and development, 16-hydroxyclarithromycin is utilized for studying its pharmacokinetics and pharmacodynamics, which helps in understanding its behavior in the body and its impact on therapeutic outcomes. Additionally, its potential interactions with other drugs are investigated to ensure safe and effective combination therapies.
Used in Drug Formulation:
16-hydroxyclarithromycin is employed in the formulation of various pharmaceutical products, such as tablets, capsules, and injectables, to provide effective treatment options for bacterial infections. Its presence in these formulations contributes to the overall efficacy and sustained action of the antibiotic, ensuring better patient outcomes.
Used in Drug Interaction Studies:
In the context of drug interaction studies, 16-hydroxyclarithromycin is used to evaluate its compatibility with other medications, ensuring that potential adverse effects or reduced efficacy are minimized. This is essential for the development of safe and effective combination therapies in the treatment of complex infections.
Check Digit Verification of cas no
The CAS Registry Mumber 124412-58-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,4,1 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.Calculate Digit Verification of CAS Registry Number 124412-58:
(8*1)+(7*2)+(6*4)+(5*4)+(4*1)+(3*2)+(2*5)+(1*8)=94
94 % 10 = 4
So 124412-58-4 is a valid CAS Registry Number.
InChI:InChI=1/C38H69NO14/c1-14-26-38(9,46)30(43)22(5)27(41)19(2)16-37(8,48-13)32(53-34-28(42)25(39(10)11)15-20(3)49-34)23(6)29(24(18-40)33(45)51-26)52-35-31(44)36(7,47-12)17-21(4)50-35/h19-26,28-32,34-35,40,42-44,46H,14-18H2,1-13H3
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16-hydroxyclarithromycin
