124414-07-9Relevant articles and documents
Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding
Mügge, Carolin,Marzo, Tiziano,Massai, Lara,Hildebrandt, Jana,Ferraro, Giarita,Rivera-Fuentes, Pablo,Metzler-Nolte, Nils,Merlino, Antonello,Messori, Luigi,Weigand, Wolfgang
, p. 8560 - 8570 (2015)
We recently characterized a series of novel platinum(II) compounds bearing a conserved O,S binding moiety as a bifunctional ligand and evaluated their solution behavior and antiproliferative properties in vitro against a representative cancer cell line. O
Platinum(ii) O,S complexes as potential metallodrugs against Cisplatin resistance
Hildebrandt, Jana,H?fner, Norman,G?rls, Helmar,Kritsch, Daniel,Ferraro, Giarita,Dürst, Matthias,Runnebaum, Ingo B.,Merlino, Antonello,Weigand, Wolfgang
supporting information, p. 18876 - 18891 (2016/12/09)
We report on platinum(ii) complexes with different cinnamic acid derivatives as ligands with cytotoxic activity against Cisplatin resistant ovarian cancer cell line subcultures of SKOV3 and A2780. A typical mechanism of action for platinum(ii) complexes a
HCV POLYMERASE INHIBITORS
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Page/Page column 50, (2015/03/28)
The invention provides compounds of the formula:(I) wherein B is a nucleobase selected from the groups (a) to (d) and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.