124424-25-5 Usage
Description
1-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione is a synthetic nucleoside analog with potent antiviral properties. It is a modified version of cytarabine, a nucleoside used in the treatment of leukemia and lymphoma. 1-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione's structure has been enhanced by the addition of a fluorine atom and alteration of the pentofuranose ring, which significantly boosts its capacity to inhibit viral DNA and RNA replication. This unique chemical compound is currently under investigation for its potential in treating various viral infections, such as hepatitis and HIV, and holds promise for the development of novel antiviral medications.
Uses
Used in Pharmaceutical Industry:
1-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione is used as an antiviral agent for its ability to inhibit the replication of viral DNA and RNA. Its application is particularly relevant in the treatment of viral infections like hepatitis and HIV, where it demonstrates significant potential in controlling and managing these diseases.
Used in Research and Development:
In the field of medical research, this compound serves as a valuable asset for the development of new antiviral drugs. Its unique structure and enhanced antiviral activity make it an attractive candidate for further study and potential incorporation into future therapeutic strategies against viral infections.
Used in Virology:
1-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione is utilized in virology as a research tool to better understand the mechanisms of viral replication and the development of resistance to antiviral treatments. Its application in this field aids in the advancement of knowledge and the creation of more effective antiviral therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 124424-25-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,4,2 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 124424-25:
(8*1)+(7*2)+(6*4)+(5*4)+(4*2)+(3*4)+(2*2)+(1*5)=95
95 % 10 = 5
So 124424-25-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H11FN2O4/c10-6-3-5(4-13)16-8(6)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4H2,(H,11,14,15)/t5-,6-,8+/m0/s1
124424-25-5Relevant articles and documents
2'-fluorofuranosyl derivatives and novel method of preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
-
, (2008/06/13)
A compound has the formula STR1 wherein R is selected from the group consisting of (C7 -C20)aroyl, (C6 -C20)aryl, aralkyl and alkylaryl, and (C1 -C10)alkyl-di(C6 -C20)aryl Si, R' is selected from the group consisting of (C1 -C10)alkyl, (C7 -C20)aroyl and (C2 -C12)acyl, all of which may be further substituted with O, S, N or alkyl, and R'" is selected from the group consisting of halogen, (C1 -C10)alkoxy, (C1 -C10)acyloxy, O-methane-sulfonyl and O-p-toluenesulfonyl. A composition of matter comprises 0.001 to 99.999 wt % of the above compound.
Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)
Martin,Bushnell,Duncan,Dunsdon,Hall,Machin,Merrett,Parkes,Roberts,Thomas,Galpin,Kinchington
, p. 2137 - 2145 (2007/10/02)
A range of 2'-fluoro and 2',3'-difluoro analogues of pyrimidine deoxyribonucleosides have been synthesized and evaluaed against human immunodeficiency virus (HIV-1) in a human lymphoblastoid cell line. Among these compounds, 1-(2,3-dideoxy-2-fluoro-β-D-threopentofuranosyl)cytosine (12), 2',3'-didehydro-2',3'-dideoxy-2'-fluorocytidine (35), 1-(2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)cytosine (41), and 3'-deoxy-2',3'-didehydro-2'-fluorothymidine (45) were found to have significant antiviral activity, with IC50 values of 0.65, 10, 10, and 100 μM, respectively. The structure-activity relationships are discussed.
